Oncoral ™


Evaluating Oral Cancer Risk by Testing Human Saliva


Oral cancer disease is the consequence of prolonged presence of specific carcinogenic molecules from alcohol/tobacco or cell integration of Human Papilloma Virus (HPV) into oral cavity.

Institut clinident developed a new strategy for oral cancer risk measurement using stabilized saliva for HPV identification and saliva volatolomics analysis. The method and the volatolomics profile of saliva in relation with oral cancer has been patented by the laboratory.

Only 36% of all oral cancers are currently detecting in their early stages.

  • When oral cancer is detected in its later stages, the five-year survival rate is approximately 50%
  • When oral cancer is detected in its early stages, the five-year survival rate is more than 80%
  • A group of VOCs have been identified to be significantly associated with an increasing risk of oral cancer at early development


  • Doctors will be able to use the results to classify these cancers as HPV positive or negative and offer treatment accordingly.
  • Classifying the HPV status of the cancer can offer eligible patients less intensive treatment with reduced side-effects. “get the most appropriate treatment for their cancer”.

Oral cancer symptoms and signs?

  • Persistent mouth sore: A sore in the mouth that does not heal is the most common symptom of oral cancer
  • Pain: Persistent mouth pain is another common oral cancer sign
  • A lump or thickening in the cheek
  • A white or red patch on the gums, tongue, tonsil, or lining of the mouth
  • A sore throat or feeling that something is caught in the throat that does not go away
  • Difficulty swallowing or chewing
  • Difficulty moving the jaw or tongue
  • Numbness of the tongue or elsewhere in the mouth
  • Jaw swelling that makes dentures hurt or fit poorly
  • Loosening of teeth
  • Pain in teeth or jaw
  • Voice changes
  • A lump in the neck
  • Weight loss
  • Persistent bad breath

Technical recommendations and OncoralTM objectives:

It is advised to carry out an analysis in the following situations:

  • Patient with any symptoms or signs
  • Patient that smoke (more than 45 years old)
  • Patient that drink (more than 45 years old)
  • Patient with poor oral hygiene
  • Patient with genital HPV or other HPV infection
  • 6 months after the first positive oral saliva test
  • Annually for all patients at risk

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